Wyniki wyszukiwania dla: Jan Oosting

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artykuł

Performance of a HER2 testing algorithm specific for p53‐abnormal endometrial cancer

Lisa Vermij, Naveena Singh, Alicia Leon‐Castillo, Nanda Horeweg, więcej

Aims Human epidermal growth factor receptor 2 (HER2) amplification in endometrial cancer (EC) is almost completely confined to the p53‐abnormal (p53abn) molecular subtype and independent of histological subtype. HER2 testing should therefore be molecular subtype‐directed. However, the most optimal approach for HER2 testing in EC has not been fully established. Therefore, we developed an EC‐specific...

artykuł

Genome‐wide characterization of 5‐hydoxymethylcytosine in melanoma reveals major differences with nevus

Catarina Salgado, Jan Oosting, Bart Janssen, Rajiv Kumar, więcej

Genes, Chromosomes and Cancer > 59 > 6 > 366 - 374

Melanoma demonstrates altered patterns of DNA methylation that are associated with genetic instability and transcriptional repression of numerous genes. Active DNA demethylation is mediated by TET enzymes that catalyze conversion of 5‐methylcytosine (mC) to 5‐hydroxymethylcytosine (hmC). Loss of hmC occurs in melanoma and correlates with disease progression. Here we analyzed the genomic distribution...

artykuł

Correction to: KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study

Lindsay C. Hewitt, Yuichi Saito, Tan Wang, Yoko Matsuda, więcej

Gastric Cancer > 2019 > 22 > 6 > 1204-1205

In the original publication of this article, Fig. 2 was published incorrectly. The correct Fig. 2 is given in this correction.

artykuł

KRAS status is related to histological phenotype in gastric cancer: results from a large multicentre study

Lindsay C. Hewitt, Yuichi Saito, Tan Wang, Yoko Matsuda, więcej

Gastric Cancer > 2019 > 22 > 6 > 1193-1203

Background Gastric cancer (GC) is histologically a very heterogeneous disease, and the temporal development of different histological phenotypes remains unclear. Recent studies in lung and ovarian cancer suggest that KRAS activation (KRASact) can influence histological phenotype. KRASact likely results from KRAS mutation (KRASmut) or KRAS amplification (KRASamp). The aim of the study was to investigate...

artykuł

Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer

Tessa P. Sandberg, Maaike P. M. E. Stuart, Jan Oosting, Rob A. E. M. Tollenaar, więcej

BMC Cancer > 2019 > 19 > 1 > 1-9

Background The tumor microenvironment has a critical role in regulating cancer cell behavior. Tumors with high stromal content are associated with poor patient outcome. The tumor-stroma ratio (TSR) identifies colorectal cancers (CRC) with poor patient prognosis based on hematoxylin & eosin stained sections. The desmoplastic reaction consists to a great extent of cancer-associated fibroblasts (CAFs)...

artykuł

Imprinted survival genes preclude loss of heterozygosity of chromosome 7 in cancer cells

Arnoud Boot, Jan Oosting, Noel FCC de Miranda, Yinghui Zhang, więcej

The Journal of Pathology > 240 > 1 > 72 - 83

The genomes of a wide range of cancers, including colon, breast, and thyroid cancers, frequently show copy number gains of chromosome 7 and rarely show loss of heterozygosity. The molecular basis for this phenomenon is unknown. Strikingly, oncocytic follicular thyroid carcinomas can display an extreme genomic profile, with homozygosity of all chromosomes except for chromosome 7. The observation that...

artykuł

Copy number alterations and allelic ratio in relation to recurrence of rectal cancer

Inès J Goossens-Beumer, Jan Oosting, Wim E Corver, Marjolein Jfw Janssen, więcej

BMC Genomics > 2015 > 16 > 1 > 1-12

Background In rectal cancer, total mesorectal excision surgery combined with preoperative (chemo)radiotherapy reduces local recurrence rates but does not improve overall patient survival, a result that may be due to the harmful side effects and/or co-morbidity of preoperative treatment. New biomarkers are needed to facilitate identification of rectal cancer patients at high risk for local recurrent...

artykuł

Near‐haploidization significantly associates with oncocytic adrenocortical, thyroid, and parathyroid tumors but not with mitochondrial DNA mutations

Willem E. Corver, Tom Wezel, Kees Molenaar, Melanie Schrumpf, więcej

Genes, Chromosomes and Cancer > 53 > 10 > 833 - 844

Mitochondrial‐rich oncocytic thyroid tumors frequently show near‐haploidization and endoreduplication (masked haploidization), which manifests as a near‐homozygous genome (NHG). We now extend this investigation to include adrenocortical cancer and parathyroid carcinoma (PaTC), which we studied for a NHG in association with mitochondrial DNA mutations. Sixty endocrine tumors from 59 patients were studied,...

artykuł

Screening for Potential Targets for Therapy in Mesenchymal, Clear Cell, and Dedifferentiated Chondrosarcoma Reveals Bcl-2 Family Members and TGFβ as Potential Targets

Jolieke G. van Oosterwijk, Danielle Meijer, Maayke A.J.H. van Ruler, Brendy E.W.M. van den Akker, więcej

The American Journal of Pathology > 2013 > 182 > 4 > 1347-1356

The mesenchymal, clear cell, and dedifferentiated chondrosarcoma subtypes are extremely rare, together constituting 10% to 15% of all chondrosarcomas. Their poor prognosis and lack of efficacious treatment emphasizes the need to elucidate the pathways playing a pivotal role in these tumors. We constructed tissue microarrays containing 42 dedifferentiated, 23 clear cell, and 23 mesenchymal chondrosarcomas...

artykuł

Maffucci syndrome: A genome‐wide analysis using high resolution single nucleotide polymorphism and expression arrays on four cases

Twinkal C. Pansuriya, Jan Oosting, Suzan H. M. Verdegaal, Adrienne M. Flanagan, więcej

Genes, Chromosomes and Cancer > 50 > 9 > 673 - 679

Ollier disease and Maffucci syndrome are rare, nonhereditary skeletal disorders characterized by the presence of multiple enchondromas with (Maffucci) or without (Ollier) co‐existing multiple hemangiomas of soft tissue. Enchondromas can progress toward central chondrosarcomas. PTH1R mutations are found in a small subset of Ollier patients. The genetic deficit in Maffucci syndrome is unknown. Here,...

artykuł

Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations

Willem Ernst Corver, Natalja Tatjana Haar, Gert Jan Fleuren, Jan Oosting

Cellular Oncology > 2011 > 34 > 6 > 553-563

Background Cancer-associated fibroblasts (CAFs) have been recognized as important contributors to cancer development and progression. However, opposing evidence has been published whether CAFs, in addition to epigenetic, also undergo somatic genetic alterations and whether these changes contribute to carcinogenesis and tumour progression. Methods We combined multiparameter DNA flow cytometry, flow-sorting...

artykuł

Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas

Marjo Puijenbroek, Anneke Middeldorp, Carli M. J. Tops, Ronald Eijk, więcej

Familial Cancer > 2008 > 7 > 4 > 319-330

Mismatch repair deficiency in tumors can result from germ line mutations in one of the mismatch repair (MMR) genes (MLH1, MSH2, MSH6 and PMS2), or from sporadic promoter hypermethylation of MLH1. The role of unclassified variants (UVs) in MMR genes is subject to debate. To establish the extend of chromosomal instability and copy neutral loss of heterozygosity (cnLOH), we analyzed 41 archival microsatellite...

artykuł

Reply

Albert-Jan Oosting, Marjolein S. de Bruin-Weller, Carla A.F.M. Bruijnzeel-Koomen

The Journal of Allergy and Clinical Immunology > 2003 > 111 > 1 > 203-204

artykuł

Effect of mattress encasings on atopic dermatitis outcome measures in a double-blind, placebo-controlled study: The Dutch mite avoidance study

Albert-Jan Oosting, Marjolein S. de Bruin-Weller, Ingrid Terreehorst, Zana Tempels-Pavlica, więcej

The Journal of Allergy and Clinical Immunology > 2002 > 110 > 3 > 500-506

Background: House dust mite (HDM) allergen might induce and maintain atopic dermatitis (AD). Reduction of allergen load by applying encasings might improve the clinical symptoms of AD. Objective: We sought to investigate, in a randomized, double-blind, placebo-controlled study, whether reducing HDM allergen levels by using mattress, duvet, and pillow encasings for 12 months will result in improvement...

artykuł

Timed inhibition of the renin-angiotensin system suppresses the rise in blood pressure upon awakening in spontaneously hypertensive rats

Jan Oosting, Harrie A. Struijker-Boudier, Ben J. Janssen

American Journal of Hypertension > 1999 > 12 > 11 > 1109-1118

In this study we investigated whether timed administration of drugs that inhibit the renin-angiotensin system can be used to blunt the rise in blood pressure that occurs during the transition from the resting to the active period of the day. For this purpose we compared in spontaneously hypertensive rats (SHR) the antihypertensive efficacy of the angiotensin converting enzyme (ACE) inhibitors captopril...

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Springer (6)
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Genes, Chromosomes and Cancer (3)
Gastric Cancer (2)
The Journal of Allergy and Clinical Immunology (2)
American Journal of Hypertension (1)
BMC Cancer (1)
BMC Genomics (1)
Cellular Oncology (1)
Familial Cancer (1)
Histopathology (1)
The American Journal of Pathology (1)
The Journal of Pathology (1)
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