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Aims
The aim of this study was to develop a population pharmacokinetic (PK) model to simultaneously describe both total and unbound concentrations of ciprofol and its major glucuronide metabolite, M4, and to link it to the population pharmacodynamics (PD) model in subjects with various renal functions.
Methods
A total of 401 and 459 pairs of total and unbound plasma concentrations of ciprofol and...