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Elevated concentrations of doxorubicin are found in eccrine sweat glands of the palms and soles. We therefore evaluated an antiperspirant as preventive treatment for palmar–plantar erythrodysesthesia (hand–foot syndrome) in patients with metastatic breast cancer treated with pegylated liposomal doxorubicin.An antiperspirant containing aluminum chlorohydrate or placebo cream was applied to the left...
Hand–foot syndrome (HFS) is dose-limiting and the most common cumulative toxicity associated with pegylated liposomal doxorubicin (PLD). It can cause considerable discomfort and lead to therapy interruption. Numerous approaches to HFS management have been reported, but there is no consensus.Published literature (identified via Medline and internet search) and expert experience regarding HFS and its...
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