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By screening a human fetal brain cDNA library under low stringency using cDNA encoding the mouse ligand of Cek5 as a probe, we have isolated a novel cDNA belonging to theEPLGgene family. This family encodes ligands of EPH-related tyrosine kinase receptors. Since the novel gene is the eighth member of theEPLGgene family, it is designatedEPLG8.The deduced amino acid sequence ofEPLG8suggests that it...
Mouseeck,a member of theEPHgene family, has been mapped to mouse chromosome 4. The syntenic relationship between this chromosome and human chromosome 1 suggests that the humanECKgene maps to the distal short arm of human chromosome 1 (1p). Since this region is frequently deleted or altered in certain tumors of neuroectodermal origin, it is important to define the specific chromosomal localization...
By screening a human fetal brain cDNA expression library using a monoclonal anti-phosphotyrosine antibody, we have isolated a cDNA clone encoding a receptor type protein-tyrosine kinase belonging to theEPHfamily,NET(neuronally expressedEPH-related tyrosine kinase).NETshows 87% homology in nucleotide sequence and 99% homology in the deduced amino acid sequence to ratelk,suggesting thatNETis the human...
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