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Multidrug resistance (MDR), is the key reason accounting for the failure of cancer chemotherapy, remains a dramatic challenge for cancer therapy. In this study, the one‐step microfluidic fabrication of a rigid pH‐sensitive micellar nanocomplex (RPN) with tunable rigidity and acid‐switchable surface charge for overcoming MDR by enhancing cellular uptake and lysosome escape is demonstrated. The RPN...
In article number 1603109, Jiashu Sun, Haijun Yu, Xingyu Jiang, and co‐workers utilize microfluidic chips to generate rigid pH‐sensitive micellar nanocomplex (RPN) with tunable rigidity and acid‐switchable surface charge for overcoming cancer drug resistance. The functionalization of RPN is realized through the incorporation of rigid PLGA core into pH‐sensitive micelle. The RPN significantly enhances...
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