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Objective
To assess if early clinical and electroencephalography (EEG) features predict later seizure development in infants with hypoxic‐ischemic encephalopathy (HIE).
Methods
Clinical and EEG parameters <12 h of birth from infants with HIE across eight European Neonatal Units were used to develop seizure‐prediction models. Clinical parameters included intrapartum complications, fetal distress,...
ObjectiveThe site of action for antiepileptic drugs (AEDs) is within the brain; however, cerebrospinal fluid (CSF) concentration is highly variable. Lacosamide (LCM) is approved by the U.S. Food and Drug Administration (FDA) for treatment of partial‐onset seizures in adults, and has linear pharmacokinetics in serum. Penetration across the blood–brain barrier (BBB) is unknown. This study aims to provide...
Refractory status epilepticus (RSE) can lack overt clinical manifestation and is usually treated with continuous infusion of intravenous anesthetic drugs (IVADs), where the use of continuous electroencephalography (cEEG) is imperative. Ketamine has recently been shown to be effective in the treatment of RSE. We retrospectively review a cohort of 11 patients receiving ketamine as part of their treatment...
Epilepsy is a disease of recurrent seizures that can be associated with a wide variety of acquired and developmental brain lesions. Current medications for patients with epilepsy can suppress seizures; they do not cure or modify the underlying disease process. On the other hand, surgical removal of focal brain regions that produce seizures can be curative. This surgical procedure can be more precise...
Purpose: Some patients with pharmacoresistant epilepsy undergoing the Wada test experience transient shivering. The purpose of this study was to investigate various clinical and radiographic characteristics of these individuals to delineate underlying mechanisms of this phenomenon.
Methods: A systematic review of prospectively collected information on patients undergoing the Wada test was performed...
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