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Animal venoms represent a rich source of pharmacologically active peptides that interact with ion channels. However, a challenge to discovering drugs remains because of the slow pace at which venom peptides are discovered and refined. An efficient autocrine‐based high‐throughput selection system was developed to discover and refine venom peptides that target ion channels. The utility of this system...
Tierische Gifte sind eine natürliche Quelle pharmakologisch aktiver Peptide, die mit Ionenkanälen wechselwirken. In der Zuschrift auf S. 9452 ff. beschreiben R. A. Lerner, H. Zhang et al. ein Autokrin‐basiertes Auswahlverfahren für funktionelle Giftpeptide. Etwa 100 Million Giftstoffe wurden in einem einzigen Experiment untersucht, und neuartige Kv1.3‐Kanalblocker wurden entdeckt.
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