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Purpose of Review Because of its clinical relevance, extensive work has been performed to uncover the signaling pathways modulated by parathyroid hormone (PTH). This review focuses on the recent identification of novel effectors of the anabolic effect of PTH in bone. Recent Findings PTH-induced activation of PKA leads to inactivation of SIK2 and nuclear translocation of HDAC4/5. This inhibits MEF2C-dependent...
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