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Background
Oxycodone is used in children and adults for the control of acute postoperative pain. Covariate influences such as age, size, and fat mass on oxycodone pharmacokinetic parameters over the human lifespan are poorly quantified.
Methods
Pooled oxycodone time‐concentration profiles were available from preterm neonates to adults. Data from intravenous, intramuscular, buccal, and epidural...
Background
Oxycodone pharmacokinetics have been described in premature neonates through to obese adults. Covariate influences have been accounted for using allometry (size) and maturation of oxycodone clearance with age. The target concentration is dependent on pain intensity that may differ over pain duration or between individuals.
Methods
We assumed a target concentration of 35 mcg.L−1 (acceptable...
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