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S-adenosyl-l-homocysteine hydrolase (SAHH) is a ubiquitous enzyme that plays a significant role in methylation-based processes by maintaining the intracellular balance between S-adenosylhomocysteine and S-adenosylmethionine. In the past years, some analogs and derivatives of aristeromycin have been reported as a potential inhibitor of Plasmodium falciparum’s SAHH (PfSAHH), but no effective therapy...
Turmeric, since in ancient Indian traditional medicinal system, has been implicated for its therapeutic and chemopreventive properties against a broad spectrum of diseases. Curcumin, the active polyphenol from turmeric, helps to obstruct the growth of many types of cancers at various stages which include prostrate, melanoma, breast, brain tumor, pancreatic, leukemia, etc. The initiation and recurrence...
Curcumin, a golden yellow pigment present in the spice turmeric, has pleiotropic chemopreventive and therapeutic active compound against many diseases including cancer. It has been reported that curcumin acts as a topoisomerase II inhibitor and it was found that even concentration of 50 µM of curcumin in vitro is active in a similar fashion as etoposide (antineoplastic agent). Topoisomerases (type...
S-adenosyl-l-homocysteine hydrolase of Plasmodium falciparum (PfSAHH) has been reported as a potential drug target against malaria. A series of aristeromycin derivatives and analogs were designed and tested for inhibition of PfSAHH. 2-Fluoroaristeromycin has been reported as a potential inhibitor of PfSAHH. Here, we have performed the molecular dynamics simulation study of 2-Fluoroaristeromycin with...
The Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (pfSAHH) enzyme has been considered as a potential chemotherapeutic target against malaria due to the amino acid differences found on binding sites of pfSAHH related to human SAHH. It has been reported that noraristeromycin and some curcumin derivatives have potential binding with the largest cavity of pfSAHH, which is also related to the...
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