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Transforming growth factor β (TGFβ) suppresses the malignant phenotype of human colon carcinoma cells through diverse cellular pathways. Activation of β-catenin/Wnt signal pathway underlies the malignant phenotype of human colon carcinomas. The Smad family of signal transducing, sequence-specific transcription activators are mediators of TGFβ signaling. In this report, we showed that TGFβ suppressed...
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