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Mechanisms of angiotensin II and cAMP regulating the expression of angiotensin II type 1 (AT 1 ) receptor mRNA were studied in neonatal rat cardiomyocytes. Angiotensin II induced a transient decrease of AT 1 -mRNA expression in time- and dose-dependent manner. Maximal decrease (49.2+/-9.5% of control) occurred at 6 h of angiotensin II (10 nmol/l) treatment. AT 1 receptor antagonists...
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