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Aframomum melegueta is a spice widely used in African folk medicine. The chloroform soluble fraction of A. melegueta seeds yielded four new diarylheptanoids named gingerenone D (1), dihydrogingerenone A (2), dihydrogingerenone B (3), and dihydrogingerenone C (4), in addition to six known diarylheptanoids and hydroxyphenylalkanones. The most potent oestrogen receptor binding ability in an oestrogen...
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