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Nicotine, the chemical compound which causes cigarette addiction, could be responsible for some lung cancers. Evidence for genetic influence on smoking behavior and nicotine dependence has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health. Recently, the locus containing two genes encoding nicotine...
DEC1, also known as SHARP-2 or Stral3, is an important molecule in embryonic differentiation and a bHLH type transcriptional regulator. It has recently been identified to be abundantly expressed in several human tumors and might play an important role in tumor development. But its expression in gastric carcinoma is unknown. In this study we show that DEC1 was frequently expressed in six gastric carcinoma...
AFP-producing gastric carcinoma(APGC) are known to have a poorer prognosis and to show a higher incidence of liver metastasis than ordinary gastric carcinoma. Therefore, surgical resection, chemotherapy or radiotherapy is usually not satisfactory. In recent years, effects of arsenic trioxide (As2O3) on cell proliferation and induced apoptosis of solid tumors have been widely studied, while little...
Utilizing whole cell as biocatalyst instead of free or immobilized enzyme is a potential way to reduce the cost of catalyst in enzyme-catalyzed beta-D-2', 3'-unsaturated-5-fluorocytidine (D-D4FC). In this paper, D-D4FC was successfully synthesized by the whole cell of Lactobacillus helveticus (ATCC10697) for the first time. Several experimental parameters including reaction time, concentration of...
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