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BMPs have been implicated in the development of bone metastasis in prostate cancer. We investigated the role of BMP-10 in prostate cancer and prostate cancer cells.BMP-10 expression was examined in human prostate tissue and prostate cancer cell lines. BMP-10 was experimentally over expressed in human prostate cancer cells. The influence of BMP-10 on the biological behavior of prostate cancer cells...
We investigated the effect of manipulating endogenous BMP-7 expression on the invasion and motility of prostate cancer cells and the resulting effect on its antagonists using a ribozyme transgene.A hammerhead ribozyme transgene was synthesized and cloned into a mammalian expression vector (pcDNA3.1/nt-GFP-TOPO). PC-3 cells (American Type Culture Collection, Manassas, Virginia) were transfected with...
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