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Hematopoietic stem cells (HSCs) have two defining features, multipotency and self‐renewal, both of which are tightly controlled by cell autonomous programs and environmental factors throughout the lifetime of an organism. During development, HSCs are born in the aorta‐gonad‐mesonephros region, and migrate to distinct hematopoietic organs such as the placenta, fetal liver and spleen, continuously self‐renewing...
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