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A series of C4′-substituted oleandrin analogues were designed, synthesized and evaluated for their cytotoxicity towards human cervical carcinoma cell line (HeLa). The structure-activity relationships (SARs) of these compounds were summarized in this paper, and 4′-α-amino-4′-dehydroxyloleandrin 4a (IC50=21.7nM) and 4′-β-amino-4′-dehydroxyloleandrin 4b (IC50=10.9nM) exhibited stronger cytotoxicity compared...
A series of bufalin-3-yl nitrogen-containing-carbamate derivatives 3 were designed, synthesized, and evaluated for their proliferation inhibition activities against human cervical epithelial adenocarcinoma (HeLa) cell line. The structure–activity relationships (SARs) of this new series are described in this paper. Cytotoxicity data revealed that the C3 moiety had an important influence on cytotoxic...
A series of bufalin 3-nitrogen-containing-ester derivatives (2–6) were designed, synthesized, and evaluated for their proliferation inhibition activities against human cervical epithelial adenocarcinoma (HeLa) and non-small-cell lung cancer (A549) cell lines. The structure–activity relationships (SARs) of this new series were described in this paper. Cytotoxicity data revealed that C3 moiety had important...
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