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To evaluate the efficacy and dose–response effect of eszopiclone on sleep latency and sleep maintenance in Japanese patients with primary insomnia.In this randomized, double-blind, five-way crossover study, 72 patients received placebo, eszopiclone 1mg, 2mg, and 3mg, and zolpidem 10mg in random order for two consecutive nights with a washout period between treatments. Objective sleep measures from...
Apolipoprotein E (ApoE) phenotypes and corresponding allele frequencies were examined in 72 patients (50–90 years of age) with sporadic Alzheimer's disease (AD) and 83 elderly controls (61–96 years of age) in Hokkaido, the northern part of Japan. The frequency of the ApoE-ɛ4 allele was significantly higher in the patients with either early-onset (age <65 years) AD (0.40) or late-onset AD (0.26)...
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