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Large cell calcifying Sertoli cell tumour (LCCSCT) is a type of testicular sex cord‐stromal tumour that may occur sporadically or in the context of Carney complex and other genetic syndromes. A subset is clinically malignant, and the molecular mechanisms that drive such aggressive behaviour remain unknown.
Methods and results
We analysed 21 samples from 20 patients with LCCSCT (12 non‐metastasising...
Aims
Large cell calcifying Sertoli cell tumour (LCCSCT) is a rare testicular sex cord‐stromal tumour that primarily affects young patients and is associated with Carney complex. We sought to characterise the clinicopathological features of a series of LCCSCT and evaluate the diagnostic utility of PRKAR1A immunohistochemistry (IHC).
Methods and results
The LCCSCT cohort (n = 15) had a median age...
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