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Objective
People with HIV (PWH) who are well treated on antiretroviral therapy remain at increased risk for body composition changes, including increased visceral adipose tissue (VAT) and reduced subcutaneous adipose tissue (SAT), as well as increased cardiovascular disease (CVD). The relationship between adipose compartments and coronary disease is not well understood among PWH.
Methods
A total...
Context The relationship of monocyte/macrophage activation to insulin resistance in obesity is unknown.
Objective To investigate a marker of macrophage activation, soluble CD163 (sCD163), in relationship to insulin resistance and metabolic parameters in obese and normal‐weight subjects.
Design and Participants Ninety‐five healthy subjects (65 obese and 30 normal‐weight) were studied. Plasma concentrations...
Objective Endothelial adhesion molecules like E‐selectin play an important role in leukocyte recruitment and development of atherosclerotic plaque. E‐selectin is increased in obesity, yet little is known regarding the specific factors contributing to elevated E‐selectin in obesity and whether tumour necrosis factor alpha (TNF‐alpha) increases E‐selectin in vivo in this population. The objectives...
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