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Highly regioselective acylation of 6-azauridine with fatty acid vinyl esters catalyzed by the lipase from Thermomyces lanuginosa for the preparation of its 5′-O-acyl derivatives has been successfully performed for the first time. The effects of some crucial factors on the enzymatic palmitoylation of 6-azauridine were further examined. The optimum reaction medium, molar ratio of 6-azauridine to vinyl...
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