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Pyridoxal biosynthesis lyase (PdxS) is an important player in the biosynthesis of pyridoxal 5′‐phosphate (PLP), the biologically active form of vitamin B6. PLP is an important cofactor involved in the metabolic pathway of amine‐containing natural products such as amino acids and amino sugars. PdxS catalyzes the condensation of ribulose 5‐phosphate (Ru5P), glyceraldehyde 3‐phosphate (G3P) and ammonia,...
Pyridoxal 5′-phosphate (PLP) is the biologically active form of vitamin B6 and is de novo synthesized from three substrates, dihydroxyacetone phosphate (DHAP), riburose 5-phosphate (RBP), and ammonia hydrolysed from glutamine. Glutamine amidotransferase (PdxT) catalyzes the production of ammonia from glutamine, while PdxS catalyzes the following condensation of ribulose 5-phosphate (Ru5P), glyceraldehyde-3-phosphate...
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