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We tested the hypothesis that androgens have physiological actions via non-DNA binding-dependent androgen receptor (AR) signaling pathways in males, using our genetically modified mice that express a mutant AR with deletion of the 2nd zinc finger of the DNA binding domain (AR ΔZF2 ) that cannot bind DNA. In cultured genital skin fibroblasts, the mutant AR ΔZF2 has normal ligand binding...
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