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Our previous studies indicated that α4 was involved in the toxicity of MC‐LR on the cytoskeleton via the change of PP2A activity in HEK 293. To explore the role of α4 in MC‐LR toxicity via PP2A regulation in different cell lines, the HL7702 cell overexpressing α4 protein was exposed to MC‐LR, and the change of PP2A, cytoskeletal structure, and cytoskeleton‐related proteins were investigated. The results...
Microcystin‐LR (MC‐LR) is one of the most toxic members of microcystins released by freshwater cyanobacterial. The major mechanism of MC‐LR toxicity has been attributed to its inhibition of protein phosphatases 1 (PP1) and 2A (PP2A). In our prior research, α4 protein, a regulator of PP2A, was found not only crucial for PP2A regulation but also for the overall response of HEK 293 cells encountering...
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