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Originally identified as a factor crucial for RNA polymerase (Pol) II transcriptional elongation of cellular genes, the P-TEFb kinase was subsequently shown to also serve as a specific host co-factor required for HIV-1 transcription. Recruited by either the bromodomain protein Brd4 to cellular promoters for general transcription or the HIV-1 Tat protein to the viral LTR for activated HIV-1 transcription,...
To fully understand how pathogens infect their host and hijack key biological processes, systematic mapping of intra-pathogenic and pathogen–host protein–protein interactions (PPIs) is crucial. Due to the relatively small size of viral genomes (usually around 10–100 proteins), generation of comprehensive host–virus PPI maps using different experimental platforms, including affinity tag purification-mass...
The ability to image neural activity in populations of neurons inside an intact animal, while obtaining single-cell or subcellular spatial resolution, has led to several advances in our understanding of vertebrate locomotor control. This result, first reported in a 1995 study of motoneurons in larval zebrafish, was the beginning of a series of technical developments that exploited the transparency...
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