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A measurement of antigen–antibody binding in the porous anodic alumina (PAA) waveguide layer via waveguide-assisted surface-enhanced Raman spectroscopy (SERS) was demonstrated. The highest SERS signals of dye-labeled antibody molecules were recorded under the waveguide resonance modes, where most of the light is confined in the waveguide layer to generate localized surface plasmon resonance of Ag...
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