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There is an urgent need to discover or predict DDIs, which would cause serious adverse drug reactions. However, preclinical detection of DDIs bear high cost. Similarity-based computational approaches can be the assistance of experimental approaches. Utilizing pre-market drug similarities, they are able to predict DDIs on a large scale. However, they neglect the topological structure among DDIs and...
It is an urgent need to understand the structure-function relationship in proteomic era. One of the important techniques to meet this demand is to analyze and represent the spatial structure of domain which is the functional unit of the whole protein, and perform fast domain classification. In this paper, we introduce a novel method of rapid domain classification. Instead of analyzing directly protein...
In tennis match highlights mainly take place in shots containing full court (Court view shots), therefore successful court view shots detection is useful for highlights extraction. This paper proposes a court view shots detection algorithm, in which shot detection that is the precondition of usual shot classification is given up for shot detection not only costs more time, but also its detection performance...
In order to extract compact and effective feature to characterize protein structure, this paper presents a feature extraction of protein fold by mapping into 2-D distance matrix which is regarded as gray level image and further analyzed by image processing techniques. Firstly, gray level co-occurrence matrix (CoM) of distance matrix image (DMI) is calculated and its singular values are taken as the...
One of the most important research aims is to understand the relationship between structure and function of protein. Inspired by this motivation, automatic classification of protein structure becomes one of major research approaches. However, how to extract compact and effective feature to characterize protein structure is still a challenge to it. In this paper, 3-D tertiary structure of protein fold...
A multi-level semantic modeling method, which integrates support vector machines (SVM) into hybrid Bayesian networks (HBN), is proposed in this paper. SVM discretizes the continuous variables of medical image features by classifying them into finite states as middle-level semantics. Based on the HBN, the semantic model for medical image semantic retrieval can be designed at multi-level semantics....
A novel two-phase support vector clustering (TPSVC) algorithm is proposed in this paper, which is implemented in multi-relational data mining (MRDM). Based on the designed kernel which is incorporated with MRDM environment, TPSVC provides an appreciate description of cluster contours using support vectors at the first step and then a support vector machine (SVM) classification procedure is employed...
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