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To improve the transfection efficiency of foreign plasmid DNA, water soluble polycation, disulfide containing polyamidoamine, was modified by introducing hydrophobic long-chain alkyl groups into the polymer backbone via quaternization with 1-bromohexadecane. Micelles, self-assembled from this amphiphilic polycation by dialysis, could condense DNA into compact nanoparticles with positive surface charges,...
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