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Seit hunderten von Jahren essen die Menschen scharfe Chilischoten, obwohl diese das Toxin Capsaicin enthalten. Diese Substanz bindet und aktiviert den TRPV1‐Kationenkanal, der vor allem in sensorischen Nervenzellen exprimiert wird. Zusätzlich wird der TRPV1‐Kanal durch Hitze, Protonen und verschiedene Toxine von Tieren aktiviert. Er dient daher als ein polymodaler Nozisensor für unterschiedliche schädliche...
The signalling via G protein-coupled receptor (GPCR) stimulation is complex, as a particular GPCR may activate more than one G protein. A ligand can also activate several GPCRs with different G protein coupling specificity. To reduce the complexity of GPCR signalling, “G protein coupled designer receptors exclusively activated by designer drugs” (DREADDs) have been developed that can be activated...
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