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HT22 immortalized hippocampal neurons serve as a cellular model system to study oxidative stress, an imbalance of cellular redox homeostasis. Glutamate induces HT22 cell death by inhibiting the uptake of cystine into the cells via the cystine/glutamate transport system x c- , thus leading to reduced levels of glutathione. Here, we show that glutamate-induced cell death is attenuated in...
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