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Optogenetics is a recently developed technique that has been widely implemented in the field of neuroscience. Channelrhodopsins (ChR), i.e., proteins that function as optically activated ion channels, are introduced into neurons either by viral transduction or transgenic manipulations. Recent advances in focused ultrasound (FUS) offer an alternative, non-invasive approach to carrying out viral transduction...
Direct infusion to the brain is a frequently used technique in pre-clinical neuroscience research as well as several clinical applications. The relatively high intracranial pressure is one of the limiting factors that hinder efficient diffusion from the cannula tip. In this study, we utilized focused ultrasound (FUS) and microbubbles to condition the brain prior to performing the direct infusion....
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