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Aim. To test for α2 adrenergic modulation of dopamine D2/3 receptor availability in striatum of living mice using the high‐affinity ligand [18F]fallypride and microPET. Methods. Groups of anesthetized mice were pretreated with saline, the α2‐agonist clonidine (1 mg/kg), and the α2‐antagonists RX821002 (1 mg/kg) and yohimbine (1 mg/kg). Dynamic microPET recordings lasting 120 min were then initiated...
Aim. Molecular imaging studies with benzamide radioligands can reveal competition from endogenous binding at D2/3‐receptors in living brain. However, single photon emission computed tomography (SPECT) methods suffer from limited spatial resolution, and [11C]‐labeled ligands are only available at positron emission tomography (PET) research sites with cyclotron‐radiochemistry facilities, whereas [18...
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