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In article number 1903254, Jia Guo, Yu Chen, Huixiong Xu, and co‐workers fabricate ultrasmall dual‐targeting iridium nanocrystals modified with tumor cell‐targeting RGD peptides and nucleus‐targeting TAT proteins for effective tumor localization and nucleus targeting, inducing prominent sensitized tumor radiotherapy.
Prominent tumor‐cell nucleus targeting of radiosensitizer substantially affects the therapeutic consequence of advanced tumor radiotherapy via lethal nucleus DNA damage. Herein, ultrasmall iridium nanocrystals (Ir NCs, <5 nm) are constructed for efficient tumor‐specific photonic hyperthermia‐synergized radiotherapy. To endow the NCs with qualified cell nucleus‐targeting performance, polyethylene...
Purpose Obstructive sleep apnea hypopnea syndrome (OSAHS) is characterized by intermittent hypoxia during sleep time, followed by oxidative stress. Hypoxia-induced oxidative stress can lead to DNA damage, which is related to chromosome aberrations and micronuclei. The purpose of this study is to investigate the level of DNA damage in peripheral blood of patients with OSAHS. Methods Thirty patients...
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