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Purpose The aim of this study was to evaluate the effect of combining human parathyroid hormone (1–34) (PTH1–34; PTH) and menaquinone-4 (MK-4) on calvarial bone defect repair in osteopenic rats. Methods Fourteen week olds were subject to craniotomy for the establishment of osteopenic animal models fed through a chronically low-protein diet. After that, critical calvarial defect model was established...
The objective of this study was to investigate the effects of human parathyroid hormone (1–34) (PTH1–34; PTH) plus menaquinone-4 (vitamin K2; MK) on the osseous integration of hydroxyapatite (HA)-coated implants in osteoporotic rats. Ovariectomized female Sprague–Dawley rats were used for the study. Twelve weeks after bilateral ovariectomy, HA-coated titanium implants were inserted bilaterally in...
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