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A growing number of studies demonstrate that valproic acid (VPA), an anti-convulsant and mood-stabilizing drug, is neuroprotective against various insults. This study investigated whether treatment of ischemic stroke with VPA ameliorated hippocampal cell death and cognitive deficits. Possible mechanisms of action were also investigated.Global cerebral ischemia was induced to mimic ischemia/reperfusion...
Human CCL17/TARC (hCCL17) and CCL22/MDC (hCCL22) interact with their receptor CCR4, playing pivotal roles in various Th2 cell-dominant diseases. Rat Ccl17, Ccl22 and Ccr4 share 63.4%, 65.2% and 87.5% homology at the amino acid level, respectively, compared with their human homologues. Rat Ccl22 has been demonstrated to interact with rat Ccr4. However, it is not known whether rat Ccl17 is a functional...
Separation of land surface temperature (LST) and emissivity from the remote sensing data is crucial to the urban energy consumption estimation. The difficulty of the TES method is that a single multispectral thermal measurement with N bands presents N equations with N+1 unknown parameters (N spectral emissivities and one land surface temperature).Accordingly, the simultaneous estimation is an underdetermined...
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