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Decisions must be made regarding screening and treatment strategies under budget constraints for chronic hepatitis C birth-cohorts in the U.S. A Markov model of disease progression is able to evaluate health utility gain using quality-adjusted life years (QALYs) for each strategy. Through conducting a simulation optimization algorithm, Probabilistic Branch and Bound (PBnB), we not only provide an...
We present a simulation optimization algorithm called probabilistic branch and bound with confidence intervals (PBnB with CI), which is designed to approximate a level set of solutions for a user-defined quantile. PBnB with CI is developed for both deterministic and noisy problems with mixed continuous and discrete variables. The quality of the results is statistically analyzed with order statistic...
We present a probabilistic branch-and-bound (PBnB) method for locating a subset of the feasible region that contains solutions in a level set achieving a user-specified quantile. PBnB is designed for optimizing noisy (and deterministic) functions over continuous or finite domains, and provides more information than a single incumbent solution. It uses an order statistics based analysis to guide the...
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