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Currently, the clinical application of protein/peptide therapeutics is mainly limited to the modulation of diseases in extracellular spaces. Intracellular targets are hardly accessed, owing largely to the endosomal entrapment of internalized proteins/peptides. Here, we report a strategy to design and construct peptides that enable endosome‐to‐cytosol delivery based on an extension of the “histidine...
A histidine‐rich endosomal escape peptide, as described by Juanjuan Du et al. in their Research Article (e202304692), is capable of mediating efficient endosome‐to‐cytosol transport of peptide/protein cargo, depicted in the cover picture as butterflies escaping from bubbles trapping them. Once combined with antibody‐mediated endocytosis, this strategy enables cell‐specific cytosolic delivery of functional...
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