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The purpose of this study is to measure the cell motility under different stiffness and pattern of the substrata. Human melanoma cells were used for this study. Three surface patterns including flat, 6 µm-cone, and 6 µm-groove on polydimethylsiloxane (PDMS) were created by the micro-electro-mechanical system (MEMS). Glass dish was used as control substrate. After cells were seeded for 30 min, the...
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