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The introduction of nanometric contrast agents to optical imaging is helpful for the understanding of some biological processes at the molecular level, as well as the development of diagnostic tools and therapies. Optical imaging agents such as gold nanorods (GNRs), quantum dots (QDs), and organically modified silica (ORMOSIL) nanoparticles can overcome many drawbacks of conventional agents, such...
A sensitive biosensor based on localized surface plasmon resonance of gold nanorods is fabricated to detect streptavidin. Gold nanorods are immobilized on glass through BSA-biotin instead of chemisorbed method. The detection limit is 1 muM.
Enhancement of fluorescence of streptavidin conjugated with gold nanorods (GNRs) was observed. The impact of GNRs with different surface plasmon resonance bands and different concentrations to the efficiency of the fluorescence enhancement was studied.
We report an effective method to synthesize gold nanorods with tunable longitudinal extinction peak wavelength from 781 to 955 nm depending on the amount of NaCl added. Those as-prepared gold nanorods are helpful for bioimaging.
Organically modified silica nanoparticles, doped with photosensitizers, are synthesized, characterized and used for photodynamic therapy (PDT) of cancer. These nanoparticles were uptaken by tumor cells in vitro and the effect of photon-induced toxicity was demonstrated.
Plasmon-resonant gold nanorods were used as high absorption contrast agents for optical coherence tomography (OCT). It is shown that nanorods imaging, with resonance wavelengths overlapping OCT source, can provide more information than conventional OCT images.
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