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Pleuromutilin derivatives 4a–h, 5a–g, and 6a–d were synthesized and characterized by IR, 1H NMR, and 13C NMR. All synthetic compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus (ATCC 25923), methicillin‐resistant S. aureus (MRSA, ATCC 43300), Pasteurella multocida (CVCC 408), Escherichia coli (ATCC 25922), and Salmonella typhimurium (ATCC 14028). Most compounds...
A series of novel 7‐azaisoindigo derivatives 3–14 were designed, synthesized, and structurally characterized by IR, 1H‐NMR, 13C‐NMR, mass spectra, and elemental analyses. Their antiproliferative activities were evaluated in a hormone‐independent prostate cancer cell line DU145. Among them, compounds 8, 9, 14 showed the highest activities. Our study also showed that compounds 7, 11, 12 exhibited higher...
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