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Key points
Adiponectin is an adipokine with anti‐inflammatory and anti‐diabetic properties. Hypoadiponectinaemia is closely associated with endothelial dysfunction and insulin resistance in obesity and diabetes.
Insulin resistance is present in muscle microvasculature and this may contribute to decreased insulin delivery to, and action in, muscle.
In this study we examined whether adiponectin ameliorates...
• Ranolazine, an anti‐anginal compound, improves glycaemic control in clinical trials and increases myocardial perfusion via a direct vasodilatatory effect on coronary arteries.
• Skeletal muscle microvasculature controls the delivery of nutrient and hormones into muscle and their exchanges between plasma and muscle interstitium by providing microvascular exchange surface area.
• In this study we...
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