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Nilotinib is a potent inhibitor of tyrosine kinase BCR-ABL that penetrates the blood–brain barrier. To evaluate the effect of nilotinib in chronic cerebellar ataxia, twelve patients with chronic cerebellar ataxia nonresponsive to other treatment options (modified Rankin scale [mRS] scores: >2) and received nilotinib therapy (daily doses: 150–300mg) for >4 (range 5–16) weeks were reviewed. At...
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