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A series of ester tethered dihydroartemisinin‐3‐(oxime/thiosemicarbazide)isatin hybrids 7a–p were designed, synthesized, and assessed for their antiproliferative activity against MCF‐7, MDA‐MB‐231, MCF‐7/ADR, and MDA‐MB‐231/ADR breast cancer cell lines. Among them, hybrids 7a,f (IC50: 1.33–3.84 µM) showed potent activity against triple‐negative (MDA‐MB‐231 and MDA‐MB‐231/ADR) breast cancer cell lines,...
A series of novel amyl ester tethered dihydroartemisinin‐isatin hybrids 4a–d and 5a–h were designed, synthesized, and evaluated as anti‐breast cancer agents. The synthesized hybrids were preliminarily screened against estrogen receptor‐positive (MCF‐7 and MCF‐7/ADR) and triple‐negative (MDA‐MB‐231 and) breast cancer cell lines. Three hybrids 4a,d and 5e not only were more potent than artemisinin and...
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