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Aims
RPR 102681, a cholecystokinin‐B antagonist, increased dopamine (DA) release and reduced cocaine self‐administration in animals. This pilot study sought to assess the safety and pharmacokinetics (PK) of co‐administration of RPR 102681 and cocaine, and to confirm the DA release mechanism of RPR 102681.
Methods
Sixteen cocaine‐dependent participants were randomized to either placebo or RPR102681...
A challenging question that continues to plague the field of addiction is why some individuals are more vulnerable for substance use disorders than others. Several important risk factors for substance abuse have been identified in clinical studies, including trait impulsivity and environmental stress. However, the neurobiological mechanisms that underlie the relationships remain poorly understood...
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