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In this study, we report an investigation of a panel of clonally‐derived Chinese hamster ovary (CHO) cell lines exhibiting variability in the proportion of full‐length IgG4 Fc‐fusion protein produced. The recombinant protein was found to be degraded during cell culture into four shorter “clipped” species (three of the four cleavage sites occurred at arginine residues) and preliminary analyses suggested...
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