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On the basis of the assumption that diseases with similar phenotypes are caused by functionally related genes, We describe a candidate gene prioritization method that is entirely based on mutual information of human protein-protein interactions and disease phenotypic similarities, and develop a tool named GENEDIG to calculate the mutual information concordance score between the human protein network...
Establishing a good algorithm for predicting temperature of thermostable proteins is an important issue. In this study, an improved thermostable proteins prediction method using Hurst exponent and Choquet integral regression model based on completed L-measure is proposed. The main idea of this method is to integrate the physicochemical properties, fractal property and Choquet integral regression model...
Disease genes identification is the key to the issue of human genetic diseases cure. This paper describes a new method of human genetic disease gene prediction, which is based on the relations between clinical manifestations and protein-protein interaction network. A new prediction model which is based on associated probability and Pearson correlation coefficient is also described. This mathematical...
Cancer is an aging-related disease promoted by accumulation of cellular damage under stressful environment. Many natural products, known as chemopreventive compounds, can lower the risk of cancer by enhancing cellular capacity of handling stress. Studies of molecular targets of these compounds have led to the identification of a novel transcription factor Nrf2 that is a master regulator of a major...
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