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On the basis of the assumption that diseases with similar phenotypes are caused by functionally related genes, We describe a candidate gene prioritization method that is entirely based on mutual information of human protein-protein interactions and disease phenotypic similarities, and develop a tool named GENEDIG to calculate the mutual information concordance score between the human protein network...
Disease genes identification is the key to the issue of human genetic diseases cure. This paper describes a new method of human genetic disease gene prediction, which is based on the relations between clinical manifestations and protein-protein interaction network. A new prediction model which is based on associated probability and Pearson correlation coefficient is also described. This mathematical...
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