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Formation of 3D networks is a crucial process for endothelial cells during development of primary blood vessels under both normal and pathological conditions. In order to investigate effects of oxygen microenvironment and matrix composition on the 3D network formation, an upside‐down microfluidic cell culture device capable of generating oxygen gradients is developed in this paper. In cell experiments,...
Oxygen tension and extracellular matrix compositions play important roles in network formation of endothelial cells. In article number 2006091, Yi‐Chung Tung and co‐workers develop an in vitro model using an upside‐down microfluidic device capable of generating oxygen gradients for three‐dimensional cell culture within hydrogels under controlled oxygen microenvironments.
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