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. Background: The prognosis of Borrmann type 4 gastric cancer remains poor today. The relative contributions of genetic factors and nongenetic factors to type 4 gastric cancer are unclear. The study of family history and spousal history of cancer may play an important role in the assessment of causation of this severe gastric cancer.Methods: During the period 1995–1997, 1118 consecutive patients with histologically confirmed gastric cancer (probands), including 113 with type 4 carcinoma, were admitted to the National Cancer Center Hospital. The type of carcinoma, as well as the family history of cancer in first-degree relatives and spouses of the probands, was abstracted from medical records. Family history and spousal history of cancer were compared between type 4 and other types of gastric cancer....
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