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The fluorescent marking of immature (blue) and hypertrophic (red) chondrocytes in an E17.5 mouse embryo by the Collagen, type II, alpha 1 promoter driving the expression of enhanced cyan fluorescent protein (blue) and the Collagen, type X, alpha 1 BAC driving the expression of mCherry fluorescent protein (red), respectively. See the article by Maye et al. in this issue.
We report here on the generation of a new fluorescent protein reporter transgenic mouse line, Col10a1‐mCherry, which can be used as a tool to study chondrocyte biology and pathology. Collagen, Type X, alpha 1 (Col10a1) is highly expressed in hypertrophic chondrocytes and commonly used as a gene marker for this cell population. The Col10a1‐mCherry reporter line was generated using a bacterial recombination...
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